Modalert 200 Tablet is a sleep-promoting medication used to treat excessive daytime sleepiness due to narcolepsy and other sleep disorders. It can also improve focus and concentration. It is more effective than amphetamine and does not cause the side effects of excess locomotor activity, jitteriness, or rebound effects seen with amphetamines.
What is Modafinil?
Modafinil (2-[(phenylmethyl) sulfinyl] acetamide; brand name Provigil in the United States) is a wake-promoting agent that was originally developed as a prescription medication for sleep disorders, particularly shift work sleep disorder and narcolepsy. It is a unique psychostimulant in that it has not been shown to have the typical side effects of traditional stimulants, including excess locomotor activity, jitteriness, or rebound effects (Dequardo 2002; Oskooilar 2005).
In addition to its wake-promoting effect, modafinil is also known for its mood-brightening and memory-enhancing properties. These properties have led to the drug being used off-label for various psychiatric conditions, such as narcolepsy, treatment-resistant depression, attention deficit hyperactivity disorder, myotonic dystrophy, post-anesthesia grogginess, and jet lag.
It has been suggested that the cognitive-enhancing and mood-brightening effects of modafinil are mediated through its interaction with dopamine and norepinephrine in the brain. It has been shown to increase dopamine levels in the brain and decrease reuptake of norepinephrine.
Furthermore, it has been shown to enhance memory in aging individuals and increase working memory capacity in healthy young adults. It has also been shown to reduce lethargy and fatigue in people who are under stress, such as soldiers on the battlefield or patients with cancer. These effects may be because modafinil is less likely to cause adverse cardiovascular or renal effects than conventional stimulants, such as amphetamine or cocaine.
What are the side effects of Modafinil?
Buy Modafinil Online is well-known for its waking effects but also has mood-brightening and memory-enhancing properties. These effects, combined with its relatively low liability to abuse, have led it to be trialed in a wide range of medical and psychiatric conditions treated by stimulants, including narcolepsy, age-related memory decline, idiopathic hypersomnia, attention deficit disorder, Alzheimer’s disease, depression, and shift-work sleep disorder.
The arousal and alertness-promoting effects of modafinil seem to be largely due to changes in the central catecholamine system, with both adrenergic (particularly NE) and dopamine (DA) systems involved. Elevations in extracellular monoamines measured by microdialysis are accompanied by increases in glutamate-glutamine and 5-HT levels, although the exact mechanism for these changes is unclear. The adrenergic mechanisms may involve NE-induced facilitation of the synaptic release of glutamate onto medial prefrontal cortex pyramidal cells, an effect blocked by prazosin but not by yohimbine.
Unlike amphetamines, which can trigger heart palpitations and rapid breathing, modafinil does not appear to have these side effects. However, it is important to tell your doctor if you have any underlying cardiovascular problems and to monitor your heart rate and blood pressure closely while taking modafinil. Additionally, you should avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas) or taking nonprescription products with caffeine while you are taking this medication.
What is the recommended dosage of Modafinil?
Modafinil has been shown to improve cognitive performance in patients with narcolepsy and other sleep disorders. It is also used off-label to reduce fatigue in multiple sclerosis and depression patients. It is known to work by improving the way your brain metabolizes certain neurotransmitters, especially dopamine and norepinephrine. Modafinil is similar to amphetamines, but it is less likely to raise your heart rate and blood pressure. It also does not cause a dramatic rebound hypersomnolence that can occur with some stimulants.
In controlled clinical trials, modafinil has been well tolerated and has a low liability for abuse. However, it should be used with caution in psychiatric patients because of the potential for psychotic or manic reactions.
Modafinil appears to have fewer cardiovascular side effects than amphetamines, although some patients in controlled studies experienced tachycardia or hypertension, and in one study, 3 of 38 girls aged 12 or older treated with modafinil developed dysmenorrhea. Other psychiatric side effects that have been reported in association with the use of modafinil include Tourette’s syndrome, insomnia, irritability, aggression, mania, and hallucinations.
Tell your doctor if you have a history of heart problems or high blood pressure, especially if they are uncontrolled; liver disease; glaucoma; an enlarged or weakened immune system; or a family history of mental/mood disorders (e.g., schizophrenia). Also let your doctor know if you are taking any other drugs, including prescription and nonprescription medications and herbal products, especially ones that can affect alertness (including antidepressants, barbiturates, narcotics, MAO inhibitors, and depressants).
What should I avoid while taking Modafinil?
In some cases, modafinil can cause severe and sometimes life-threatening skin reactions such as Stevens-Johnson syndrome or drug-induced hypersensitivity reaction with eosinophilia and systemic symptoms (DRESS). Seek emergency treatment if you develop any signs of these side effects, including severe rash, blisters, sores in your mouth or on your lips, or itching.
Modafinil has been shown to have cognitive-enhancing properties without the potentially harmful stimulant side effects of traditional stimulants such as jitteriness, hyperactivity, and rebound fatigue. This may be due to its mode of action and less pharmacological impact on the cardiovascular system. As a result, it is used as a wake-promoting agent and in trials on medical and psychiatric conditions that are currently treated with stimulants such as various fatigue syndromes, narcolepsy, depression, attention-deficit/hyperactivity disorder, Alzheimer’s disease, idiopathic hypersomnia, myotonic dystrophy, jet-lag, and treatment of some schizophrenia symptoms.
However, it is not a substitute for sleep or a healthy diet and lifestyle. It can also be habit-forming and should never be shared with others. Always follow the instructions on your prescription label and read all medication guides or instruction sheets. It is important to keep this medication out of reach of children and out of the heat and light. Do not flush it down a toilet or drain unless instructed to do so. Properly dispose of this medication when it is expired or no longer needed.
