The duration of Ivermectin’s presence in the body varies based on several factors, including the individual’s metabolism, dosage, and administration route. Generally, after a single oral dose, Ivermectin’s plasma concentration peaks within 4 to 6 hours, and its half-life ranges from 16 to 28 hours. This means it may take approximately 4 to 5 days for Ivermectin to be eliminated from the body.
However, in certain situations, such as repeated dosing or in individuals with impaired liver function, the elimination half-life may be prolonged. Additionally, Ivermectin undergoes hepatic metabolism, primarily by cytochrome P450 enzymes, and is excreted primarily in feces.
It’s important to note that while Ivermectin’s systemic presence may decline over time, its pharmacological effects may persist due to its prolonged activity at target sites. Always consult a healthcare professional for guidance on medication usage and duration, especially concerning off-label or unconventional uses.
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